The Week 2 NFL schedule is an intriguing mix of non-divisional battles and traditional rivalries that could have an early impact on the NFL playoff picture. Two undefeated AFC West rivals square off on Sunday when Patrick Mahomes and the Kansas City Chiefs battle Austin Ekeler and the Los Angeles Chargers. Meanwhile in the NFC South, Christian McCaffrey and the Panthers visit Tom Brady and the Tampa Bay Buccaneers. Which teams should you back with your NFL picks?
The Buccaneers enter Sunday’s showdown as nine-point favorites according to the latest Week 2 NFL odds from William Hill. The Chiefs, meanwhile, enter their matchup against the Chargers as 8.5-point favorites on the road in the current NFL spreads. All of the Week 2 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 2 NFL picks now.
The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,400 for $100 players on its top-rated NFL picks since its inception five years ago.
After going 4-0 on top-rated picks in Week 1, it enters Week 2 of the 2020 NFL season on an incredible 100-65 roll on top-rated NFL picks that dates back to the 2017 season. The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.
Top NFL predictions for Week 2
One of the top Week 2 NFL predictions the model recommends: the Ravens (-6.5) cover against the Texans. Baltimore went 10-6 against the spread in the regular season during its breakout 2019 campaign. The Ravens easily covered a seven-point spread in Week 1 against the Browns as they rolled 38-6 on Sunday.
The Ravens have historically dominated the Texans too. In fact, they are 9-2 all time straight-up, including a 41-7 blowout in their last meeting in 2019. Baltimore covered a four-point spread with over 30 points to spare in that game. SportsLine’s model is calling for more of the same from Baltimore on Sunday, as the Ravens cover in more than 60 percent of simulations, while the under (52.5) hits 60 percent of the time.
Another one of the top Week 2 NFL picks from the model: The Chiefs (-8.5) cover with room to spare on the road against the Chargers. The Chiefs began their Super Bowl title defense with a resounding 34-20 victory over the Texans. Mahomes led the charge for the Chiefs, completing 24-of-32 passes for 211 yards and three touchdowns. Rookie running back Clyde Edwards-Helaire dazzled in his NFL debut, carrying the ball 25 times for 138 yards and a score.
In addition, the Chiefs have dominated this AFC West rivalry over the years. In fact, Kansas City is 11-1 in its last 12 meetings against the Chargers. Plus, the Chiefs are a perfect 6-0 against the spread in their last six meetings against the Chargers on the road. SportsLine’s model says Mahomes and the Chiefs cover in nearly 60 percent of simulations, while the over (47) also hits more than 50 percent of the time.
How to make Week 2 NFL picks
The model also has made the call on the big Seahawks vs. Patriots matchup on Sunday Night Football as well as every other game on the Week 2 NFL schedule. It’s also identified a favorite that loses outright in a surprising upset. You can only get every pick for every game at SportsLine.
What NFL picks can you make with confidence in Week 2? And which favorite gets stunned? Check out the latest NFL odds below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,400 on its top-rated NFL picks.
NFL odds, matchups for Week 2
Cincinnati Bengals at Cleveland Browns (-6, 43.5)
Los Angeles Rams at Philadelphia Eagles (+1, 46)
New York Giants at Chicago Bears (-6.5, 42)
Atlanta Falcons at Dallas Cowboys (-5, 52)
San Francisco 49ers at New York Jets (+6.5, 42.5)
Carolina Panthers at Tampa Bay Buccaneers (-9, 49)
Detroit Lions at Green Bay Packers (-6, 47.5)
Buffalo Bills at Miami Dolphins (+5.5, 41)
Denver Broncos at Pittsburgh Steelers (-6.5, 41.5)
Minnesota Vikings at Indianapolis Colts (-3, 48)
Jacksonville Jaguars at Tennessee Titans (-9, 42.5)
Washington Football Team at Arizona Cardinals (-6.5, 46.5)
Kansas City Chiefs at Los Angeles Chargers (+8.5, 47.5)
Baltimore Ravens at Houston Texans (+6.5, 52.5)
New England Patriots at Seattle Seahawks (-4, 45)
New Orleans Saints at Las Vegas Raiders (+5.5, 51.5)